Aryloxyphenylpropylamines and their preparation and use

Details Aryloxyphenylpropylamines and their preparation and use Aryloxyphenylpropylamines and their preparation and use

C - Chemistry, Metallurgy

07

C

167/179, 260/603

C07C 217/10 (2006.01) A61K 31/135 (2006.01) C07C 217/48 (2006.01) C07C 255/54 (2006.01) C07D 317/64 (2006.01)

Patent

CA 1336195

Novel aryloxyphenylpropylamines having the formula Image wherein R1 is C3-7-cycloalkyl, C3-10-alkyl, or alkenyl which may be straight, branched or cyclic, unsubstituted or substituted with C1-4-alkoxy, aryloxy or cycloalkyl or cycloalkylalkyl, and R2 is 3,4-methylenedioxyphenyl, aryl or heteroaryl, which are optionally substituted with one or more cyano, halogen, C1-6-alkyl, C1-6-alkoxy, C1-6-alkenyl, trifluoromethyl, C3-5- alkylene, aryloxy or aralkoxy and a salt thereof with a pharmaceutically acceptable acid. The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.

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