Aryloxyphenylpropylamines their preparation and use

Details Aryloxyphenylpropylamines their preparation and use Aryloxyphenylpropylamines their preparation and use

C - Chemistry, Metallurgy

07

C

167/179, 260/603

C07C 217/62 (2006.01) A61K 31/135 (2006.01) A61K 31/275 (2006.01) A61K 31/36 (2006.01) C07C 217/48 (2006.01) C07C 217/72 (2006.01) C07C 255/59 (2006.01) C07D 317/64 (2006.01)

Patent

CA 2017468

ABSTRACT Novel aryloxyphenylpropylamines having the formula Image (I) wherein X is H, cyano, halogen, halogenoalkyl, C1-6-alkoxy, C1-6- alkyl, C1-5-alkanoyl, C3-5-alkylene, aryloxy or aralkoxy, and R is 3,4-methylenedioxy, aryl or heteroaryl which are optionally substituted with one or more cyano, halogeno, C1-6-alky, C1-6-alkoxy, C1-6-alkenyl, trifluoromethyl, C3-5- alkylene, aryloxy or aralkoxy; and R1 and R2 independently is C1-10-alkYl, C3-7-cycloalkl, C2-10-alkanyl, C3-6-cycloalkyl-C1-5-alkyl, optionally sub- stituted with C1-5-alkoxy or cyano, or R1 and R2 may together form a carbocyclic ring and a salt thereof with a pharmaceutically acceptable acid, provided however that R1 is not C3-7-cycloalkyl, C1-10- alkyl, or alkenyl which may be straight, branched or cyclic, unsubstituted or substituted with C1-4-alkoxy, aryloxy or cycloalkyl or cycloalkylalkyl, when X is H and R2 is a methyl group. The novel compounds are useful in the treatment of migraine, ischemia, epilepsy, traumatic injury and neurode- generative diseases.

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