C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 317/66 (2006.01) A23K 1/16 (2006.01) A61K 31/195 (2006.01) A61K 31/36 (2006.01) A61P 3/04 (2006.01) C07C 213/04 (2006.01) C07C 217/58 (2006.01) C07C 217/84 (2006.01) C07D 317/58 (2006.01)
Patent
CA 2270581
The invention concerns aryloxypropanolamine derivatives having at least an anti-diabetic and anti-fat activity and their methods of preparation and applications, particularly as human and veterinary medicine and animal food additive. These derivatives comply with the general formula (I) in which R>2< represents one of the following groups: -CH>2<-, -CH>2<-CH>2<, -CH(CH>3<)-CH>2<-, -C(CH>3<)=CH-, -C(CH>3<)>2<-CH>2<- or a bond; Q represents: (i) a phenyl radical 3,4-disubstituted alkylene dioxy determining with the phenyl radical, a non-substituted benzodioxane unit, a non-substituted benzodioxol unit, or a 2-substituted benzodioxol unit, (ii) a phenyl radical 3 and/or 4-substituted, by a O-(CH>2<)>x<-COOR>5< group, (iii) a condensed polycyclic hydrocarbon comprising at least two condensed cycles, (iv) a cyclic hydrocarbon system, optionally cross-linked, and constituting a cycloalkane comprising 1, 2 or 3 cycles.
Dérivés aryloxypropanolamines possédant au moins une activité anti-diabétique et anti-obésité ainsi que leurs procédés de préparation et leurs applications, notamment comme médicaments en médecine humaine et vétérinaire et comme additif alimentaire animal. Ces dérivés répondent à la formule générale (I), dans laquelle: R2 représente l'un des groupes suivants: -CH2-, -CH2-CH2, -CH(CH3)-CH2-, -C(CH3)=CH-, -C(CH3)2-CH2- ou une liaison Q représente: (i) un radical phényle 3,4-disubstitué alkylène dioxy déterminant avec le radical phényle, un motif benzodioxane non substitué, un motif benzodioxol non substitué, ou un motif benzodioxol 2-substitué, (ii) un radical phényle 3 et/ou 4-substitué, par un groupe O-(CH2),-COOR5, (iii) un hydrocarbure polycyclique condensé comprenant au moins deux cycles condensés, (iv) un système hydrocarboné cyclique, éventuellement ponté, et constituant un cycloalkane comprenant 1, 2 ou 3 cycles.
Archimbault Philippe
Elhadri Ahmed
Leclerc Gerard
Pietri-Rouxel France
Strosberg Arthur Donny
Borden Ladner Gervais Llp
Virbac S.a.
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