C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/40 (2006.01) A61K 31/495 (2006.01) C07D 207/404 (2006.01) C07D 207/408 (2006.01) C07D 211/88 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2338317
Novel piperazine derivatives substituted on one nitrogen by an aromatic system and on the other nitrogen by (2,5-dioxopyrrolidin)-1-yl) alkanes or (2,6- dioxopiperidin-1-yl) alkanes have been found to exhibit selective .alpha.1A adrenergic activity. The compounds are useful for treatment of disease conditions, such as peripheral vascular disease, congestive heart failure, hypertension and especially benign prostatic hypertrophy.
L'invention concerne de nouveaux dérivés de pipérazine substitués dans un azote par un système aromatique et dans l'autre azote par des (2,5-dioxopyrrolidine)-1-yl) alcanes ou des (2,6-dioxopyrrolidine)-1-yl) alcanes, qui manifestent une activité sélective .alpha.¿1A? adrénergique. Ces composés sont utiles pour traiter des états pathologiques tels que les acrosyndromes, l'insuffisance cardiaque globale, l'hypertension et tout particulièrement l'hypertrophie prostatique bénine.
Anand Nitya
Gupta Jang Bahadur
Jain Sanjay
Mehta Anita
Saxena Anil Kumar
Ranbaxy Laboratories Limited
Ridout & Maybee Llp
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