Arylpiperidine derivatives

Details Arylpiperidine derivatives Arylpiperidine derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/270

C07D 211/08 (2006.01) C07D 211/14 (2006.01) C07D 211/18 (2006.01) C07D 221/20 (2006.01) C07D 221/24 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 417/10 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2004249

A series of novel N-alkyl or oxyalkyl arylpiperidine derivatives have been prepared, including their pharmaceutically acceptable acid addition salts, wherein the N-alkyl side chain is further substituted by certain heterocyclic ring groups. These particular compounds are useful in therapy as neuroleptic agents for the control of various psychotic disorders and are represented by the formula: Image wherein Ar is methoxyphenyl or naphthyl; n is an integer of from two to four, inclusive; X is a direct link; and R is 2-amino-4-thiazolylphenyl, 5-oxindolyl, 2-methyl-4- oxo-4H-pyrido[1,2-a]pyrimidin-3-yl or 1,8,8-trimethyl-2,4-dioxo-3- azabicyclo-[3.2.1]octan-3-yl. Methods for preparing all these compounds from known starting materials are also disclosed.

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