C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 205/08 (2006.01) C07D 207/12 (2006.01) C07D 207/27 (2006.01) C07D 207/28 (2006.01) C07D 209/44 (2006.01) C07D 209/48 (2006.01) C07D 211/40 (2006.01) C07D 211/76 (2006.01) C07D 223/10 (2006.01) C07D 225/02 (2006.01) C07D 241/04 (2006.01) C07D 295/08 (2006.01) C07D 295/13 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2289987
This invention relates to a series of arylsubstituted piperazines, of Formula (I), pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-la adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
L'invention concerne une série de pipérazines à substitution aryle, de formule (I) et des compositions pharmaceutiques renfermant ces pipérazines ainsi que des intermédiaires utilisés dans leur élaboration. Les composés décrits inhibent de manière sélective la liaison sur adrénorécepteur alpha -1a, un récepteur intervenant dans l'adénome prostatique. En tant que tels, lesdits composés ont une utilité potentielle dans le traitement de l'adénome considéré et d'autres affections.
Jolliffe Linda
Li Xiaobing
Maryanoff Cynthia
Mulcahy Linda
Murray William
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ortho-Mcneil Pharmaceutical Inc.
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