C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/80 (2006.01) A61K 31/455 (2006.01) C07C 323/32 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2463814
According to the invention there is provided a compound the formula I; wherein : A is an optionally substituted: phenyl, naphthyl, pyridyl, pyrazinyl, pyridazinyl, paramidal, thienyl, thiazolyl, oxazolyl or thiadiazolyl; B is an optionally substituted: phenyl, pyridyl, thiazolyl, oxazolyl, thienyl, thiadiazolyl, isoxazole, pyrazole, furyl, pyrrolyl, imidazolyl, pyrazinyl, pyridazinyl, pyrimidyl, pyridone, pyrimidone, pyrazinone or pyridazinone; X is optionally substituted: pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, thienyl, furyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl or phenyl. R1 is CO2H, CO2R, COSO2NR2, tetrazolyl, P(O) or (OR)2 or SONH2. R2 is H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or C1-3 alkylaryl. R3 is H or C1-5 alkyl. R4 is H or C1-5 alkyl.
L'invention concerne un composé de formule (I), dans laquelle A désigne phényle, naphtyle, pyridyle, pyrazinyle, pyridazinyle, pyrimidyle, thiényle, thiazolyle, oxazolyle ou thiadiazolyle éventuellement substitué; B désigne phényle, pyridyle, thiazolyle, oxazolyle, thiényle, thiadiazolyle, isoxazole, pyrazole, furyle, pyrrolyle, imidazolyle, pyrazinyle, pyridazinyle, pyrimidyle, pyridone, pyrimidone, pyrazinone ou pyridazinone éventuellement substitué; X désigne pyridyle, pyrazinyle, pyrimidinyle, pyridazinyle, pyrrolyle, thiényle, furyle, imidazolyle, pyrazolyle, thiazolyle, isothiazolyle, oxazolyle, isoxazolyle ou phényle éventuellement substitué. R<sp>1</sp> désigne CO<sb>2</sb>H, CO<sb>2</sb>R, COSO<sb>2</sb>NR<sb>2</sb>, tétrazolyle, P(O) ou (OR)<sb>2</sb> ou SONH<sb>2</sb> R<sp>2 </sp>désigne H, alkyle C<sb>1-6</sb>, alcényle C<sb>2-6</sb>, alkynyle C<sb>2-6 </sb>ou alkylaryle C<sb>1-3, </sb>R<sp>3</sp><sb> </sb>désigne H ou alkyle C<sb>1-5</sb>, et R<sp>4</sp> désigne H ou alkyle C<sb>1-5</sb>.
Beauchemin Sophie
Burk Robert M.
Allergan Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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