Arylsulfonamide derivatives for use as ccr3 antagonists in...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 295/26 (2006.01) A61K 31/40 (2006.01) A61K 31/454 (2006.01) A61K 31/495 (2006.01) A61K 31/551 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 207/48 (2006.01) C07D 211/96 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2459432

The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.

L'invention concerne un dérivé de sulfonamide utile comme principe actif de préparations pharmaceutiques. Les dérivés de sulfonamide de l'invention présentent une activité antagoniste de CCR3 (récepteur de chimiokines du type CC), et peuvent être utilisés pour prévenir ou traiter des maladies associées à l'activité de CCR3, notamment l'asthme, la dermatite atopique, la rhinite allergique et d'autres affections inflammatoires/immunitaires.

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