Arylsulfonamide ethers, and methods of use thereof

Details Arylsulfonamide ethers, and methods of use thereof Arylsulfonamide ethers, and methods of use thereof

C - Chemistry, Metallurgy

07

C

C07C 311/16 (2006.01) A61K 31/075 (2006.01) A61K 31/195 (2006.01) A61K 31/24 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) C07C 311/29 (2006.01) C07C 311/42 (2006.01) C07C 311/46 (2006.01) C07C 311/47 (2006.01) C07C 317/00 (2006.01) C07C 335/18 (2006.01) C07D 207/00 (2006.01) C07D 211/06 (2006.01) C07D 215/36 (

Patent

CA 2445923

Novel arylsulfonamide ether compounds and pharmaceutical compositions thereof are described. The use of the novel arylsulfonamide ether compounds and pharmaceutical compositions thereof as inhibitors of interleukin-1.beta. converting enzyme and other cysteine proteases in the ICE family is also described. In addition, methods of treating stroke, inflammatory diseases, septic shock, repurfusion injury, Alzheimer's disease, and shigellosis using a compound of the invention or a pharmaceutical composition thereof are described.

La présente invention concerne de nouveaux composés éther arylsulfonamide et des compositions pharmaceutiques à base de ces composés. Cette invention concerne aussi l'utilisation de ces nouveaux composés éther arylsulfonamide et de ces compositions pharmaceutiques comme inhibiteurs d'enzyme de conversion de l'interleukine 1.beta. (ICE) et d'autres cystéine protéases de la famille ICE. Cette invention concerne enfin des techniques de traitement de l'apoplexie, de maladies inflammatoires, de choc septique, de lésion consécutive à la perfusion, de la maladie d'Alzheimer et de la dysenterie bacillaire, qui utilisent un composé ou une composition pharmaceutique de l'invention.

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