Arylsulfonamido-substituted hydroxamic acids as matrix...

Details Arylsulfonamido-substituted hydroxamic acids as matrix... Arylsulfonamido-substituted hydroxamic acids as matrix...

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/4406 (2006.01) A61K 31/443 (2006.01) A61K 31/4545 (2006.01) A61P 9/10 (2006.01) A61P 27/02 (2006.01) A61P 41/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2192092

Compounds of formula (I) wherein R, R1, R2 and Ar are as defined in the specification, have valuable pharmaceutical properties and are effective especially as matrix metalloproteinase inhibitors, for example for the treatment of arthritis. They are prepared in a manner known per se.

L'invention se rapporte à des composés de la formule (I) dans laquelle R, R1, R2 et Ar sont tels que définis dans la demande. Ces composés ont de précieuses propriétés pharmaceutiques et sont notamment efficaces comme inhibiteurs de métalloprotéinases matricielles, par exemple, dans le traitement de l'arthrite. Ils sont préparés d'une manière connue en soi.

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