Arylsulfone compounds

Details Arylsulfone compounds Arylsulfone compounds

C - Chemistry, Metallurgy

07

D

260/602, 260/267

C07D 333/52 (2006.01) C07D 295/092 (2006.01) C07D 295/096 (2006.01) C07D 295/10 (2006.01) C07D 333/76 (2006.01)

Patent

CA 1253503

Abstract of the Disclosure A novel sulfone compound represented by the general formula (I) Image (I) wherein R1 is cyclohexyl, phenyl; or a phenyl substituted with a group selected from nitro, C1-C3 alkyl, C1-C3 alkoxy and halogen; R2, R3, R4 and R5 are respectively hydrogen, halogen, cyano or carbonyl, wherein R1 and R2 may form an o-phenylene or an o-phenylene substituted with at least one group selected from nitro C1-C3 alkyl, C1-C3 alkoxy and halogen; X is oxygen or methylene; Y is -(CH2)n-, wherein n is an integer of 0, 5 or 6, or Image , wherein m is an integer 1-3; R6 is hydrogen, C1-C3 alkyl, .omega.-alkylaminoalkyl, wherein each alkyl has 1-3 carbon at.oms, or .omega.-dialkylaminoalkyl, wherein each alkyl has 1-3 carbon atoms; R7 is hydrogen or C1-C3 alkyl; and R6 and R7 may form a ring together with N, or Image may be Image , wherein R8 is hydrogen, C1-C3 hydroxyalkyl or phenyl; or a pharmaceutically acceptable salt thereof is disclosed. The compound has anti-ulcer effect.

504206

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