Arylsulfonic acid salts of pyrimidine-based antiviral agents

Details Arylsulfonic acid salts of pyrimidine-based antiviral agents Arylsulfonic acid salts of pyrimidine-based antiviral agents

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/506 (2006.01) A61P 31/22 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2397345

Salts of pyrimidine derivatives are provided having formula (I), wherein R represents hydrogen, methyl or ethyl; Z represents a substituted or unsubstituted 1-piperidinyl, a substituted or unsubstituted 4-morpholinyl, or a substituted or unsubstituted 1-pyrrolidinyl; and Ar represents a substituted or unsubstituted phenyl or a substituted or unsubstituted naphthyl. These salts are particularly useful as antiviral agents (e.g., to treat CMV infections).

La présente invention concerne des sels de dérivés de pyrimidine de formule (I). Dans la formule, R représente hydrogène, méthyle ou éthyle; Z représente un 1-pipéridinyle substitué ou non substitué, un 4-morpholinyle substitué ou non substitué, ou un 1-pyrrolidinyle substitué ou non substitué; et Ar représente un phényle substitué ou non substitué ou un naphtyle substitué ou non substitué. Ces sels sont particulièrement utiles en tant qu'agents antiviraux ( pour traiter les infections à cytomégalovirus par exemple).

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