Arylsulfonyl hydroxamic acid derivatives

Details Arylsulfonyl hydroxamic acid derivatives Arylsulfonyl hydroxamic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/02 (2006.01) A61K 31/445 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 211/90 (2006.01) C07D 211/96 (2006.01) C07D 241/24 (2006.01) C07D 265/30 (2006.01) C07D 279/12 (2006.01) C07D 401/02 (2006.01) C07D 413/02 (2006.01)

Patent

CA 2280151

A compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Q are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, macular degeneration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.

L'invention porte sur un composé de formule (I) dans laquelle R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, et Q sont définis ci-dessus, et pouvant servir à traiter des états tels que l'arthrite, le cancer, les ulcérations des tissus, la dégénérescence maculaire, la resténose, les parodontopathies, l'épidermolyse bulleuse congénitale, la sclérite et autres maladies caractérisées par l'activité de la métalloprotéase matricielle, le SIDA, la septicémie, le choc septique, et autres maladies entraînant la production de TNF. Ledit composé peut de plus être utilisé dans des thérapies combinées avec des anti-inflammatoires non stéroïdaux usuels et des analgésiques, et associé à des cytotoxiques tels que l'adriamycine, la daunomycine, le cisplatine, l'étoposide, le taxol, le taxotère, et d'autres alcaloïdes tels que la vincristine, dans le traitement du cancer.

Affiliated with

Also associated with

Rating

Arylsulfonyl hydroxamic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arylsulfonyl hydroxamic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arylsulfonyl hydroxamic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1416577