C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/96 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 241/04 (2006.01) C07D 241/08 (2006.01) C07D 265/30 (2006.01) C07D 279/12 (2006.01) C07D 295/24 (2006.01) C07D 401/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 471/08 (2006.01) C07D 473/00 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2218503
A compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other diseases characterized by matrix metalloproteinase activity, as well as AIDS, sepsis, septic shock and other diseases involving the production of TNF.
La présente invention décrit un composé de formule (I) dans laquelle R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9> et Ar sont tels que définis dans la description, utilisé dans le traitement de troubles choisis parmi l'arthrite, le cancer, l'ulcération des tissus, la resténose, la parodontopathie, l'épidermolyse bulleuse, la sclérite et d'autres maladies caractérisées par une activité de métalloprotéase matricielle, ainsi que le SIDA, la septicémie, le choc septique et d'autres maladies comprenant la production de TNF.
Piscopio Anthony D.
Rizzi James P.
Pfizer Inc.
Smart & Biggar
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