Arylsulfonylamino hydroxamic acid derivatives

Details Arylsulfonylamino hydroxamic acid derivatives Arylsulfonylamino hydroxamic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 295/185 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07C 303/40 (2006.01) C07C 311/19 (2006.01) C07C 311/29 (2006.01) C07D 207/12 (2006.01) C07D 211/60 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 241/08 (2006.01) C07D 295/15 (2006.01) C07D 309/14 (2006.01) C07D 335/02 (2006.01) C07D 401/02 (2006.01) C07D 403/02 (2006.01) C07D 405/0

Patent

CA 2214720

A compound of formula (I), wherein n, X, R3, R4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF.

Cette invention concerne un composé de la formule (I), dans laquelle n, X, R<3>, R<4> et Ar sont définis dans le descriptif de l'invention. Ce composé est utile dans le traitement des affections appartenant au groupe suivant: arthrite, cancer, ulcération des tissus, resténose, paradontolyse, épidermolyse bulleuse, sclérite et autres maladies caractérisées par une activité de métalloprotéinase matricielle, SIDA, septicémie, choc septique et autres maladies faisant intervenir la production du facteur de nécrose tumorale (TNF).

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