C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/34 (2006.01) A61K 31/16 (2006.01) A61K 31/33 (2006.01) C07C 317/24 (2006.01) C07C 317/46 (2006.01) C07D 211/66 (2006.01) C07D 241/12 (2006.01) C07D 309/08 (2006.01) C07D 335/02 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2490646
This invention is directed generally to hydroxamic acid and amide compounds (including salts of such compounds), and, more particularly, to aryl- and heteroaryl-~arylsulfonylmethyl hydroxamic acids and amides that, inter alia, inhibit protease activity, particularly matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. These compounds generally correspond in structure to formula (I): wherein Al, A2, A3, El, E2, E3, and E4 are as defined in this patent. This invention also is directed to compositions of such compounds, intermediates for the syntheses of such compounds, methods for making such compounds, and methods for treating conditions associated with MMP activity and/or aggrecanase activity, particularly pathological conditions.
La présente invention concerne globalement l'acide hydroxamique et les composés amide (y compris les sels de ces composés) et plus particulièrement, les acides hydroxamiques arylsulfonylméthyl aryle et héréoaryle qui, entre autres, inhibent l'activité des protéases, notamment l'activité de la métalloprotéinase matricielle (également connue sous le nom de 'métalloprotéase matricielle'' ou 'MMP'') et/ou l'activité aggrégacanase. La structure de ces composés correspond en général à la formule (I) dans laquelle A?l¿, A?2¿, A?3¿, E?l¿, E?2¿, E?3¿ et E?4¿ sont tels définis dans le descriptif. Cette invention se rapporte également à des compositions de ces composés, à des intermédiaires utiles pour effectuer la synthèse de ces composés, à des procédés de préparation desdits composés et à des méthodes de traitement d'états associés à l'activité MMP et/ou à l'activité aggrécanase, notamment les états pathologiques. Formule (1)
Becker Daniel P.
Chen Yiyuan
Freskos John N.
Gasiecki Alan F.
Grapperhaus Margaret L.
Osler Hoskin & Harcourt Llp
Pharmacia Corporation
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