Arylsulfonylimidazolone derivatives as an antitumor agent

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/12 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2263353

The present invention relates to a novel arylsulfonylimidazolone derivative represented by formula (I) which shows a superior antineoplastic activity in contrast to the known sulfonylurea antitumor agents as well as little side effect; and its pharmaceutically acceptable salt and stereoisomer, in which <u>--</u>, R1 and R2 are as defined in the specification.

L'invention se rapporte à un nouveau dérivé d'arylsulfonylimidazoline qui répond à la formule suivante (I) où <u>--</u>, R¿1? et R¿2? sont tels qu'ils sont définis dans la description, et qui possède une action antinéoplastique supérieure à celle des agents anti-tumoraux connus à base de sulfonylurée tout en ayant peu d'effets secondaires; l'invention se rapporte également à un sel pharmaceutiquement acceptable et à un stéréo-isomère dudit dérivé.

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