Arylsulphonyl-nitromethanes, process for their preparation...

Details Arylsulphonyl-nitromethanes, process for their preparation... Arylsulphonyl-nitromethanes, process for their preparation...

C - Chemistry, Metallurgy

07

D

167/208, 260/283

C07D 209/08 (2006.01) A61K 31/33 (2006.01) C07D 209/34 (2006.01) C07D 215/06 (2006.01) C07D 215/08 (2006.01) C07D 311/22 (2006.01) C07D 311/58 (2006.01) C07D 311/74 (2006.01) C07D 313/08 (2006.01) C07D 335/06 (2006.01)

Patent

CA 2025768

(57) Abstract The invention concerns novel, pharmaceutically useful, bensheterocyclyl sulphones of formula (1), in which ring A may bear optional halogeno, (1-4C)alkyl or fluoro(1-4C)alkyl substituents; X is oxygen, or a group of the formula -S(O)n- or -NR1- in which n is zero, 1 or 2 and R1 is hydrogen, (1-4C)alkyl, (1-6C)alkanoyl, benzoyl or phenyl(1-4C)alkyl, the last two optionally substituted; Y is various linking groups defined hereinafter, such as ethylene or trimethylene; and in which the group -SO2CH2NO2 is located at position a, b or c in ring A; together with the non-toxic thereof. Other aspects of the invention include the production of the novel compounds by analogy processes and pharmaceutical compositions of the novel com- pounds for use in the treatment of diabetic complications.

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