C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 285/10 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61K 31/695 (2006.01) C07D 417/12 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2199822
A novel arylthiadiazole derivative represented by general formula (I) and useful for preventive or therapeutic treatment of human viral infection, or salts thereof, and an antiviral agent containing the same, wherein R1, R2 and R3 represent each hydrogen, halogeno, C1-C6 alkyl, trifluoromethyl, C1-C4 alkoxy, hydroxy, nitro, etc.; A represents (a), (b), (c), etc.; Y1 represents oxygen or sulfur; W represents oxygen or sulfur; R4 and R5 represent each hydrogen; C1-C4 alkoxy, etc.; R9 and R10 represent each hydrogen or C1-C6 alkyl; R14 represents hydrogen, C1-C6 alkyl, etc.; and n represents 0 or 1.
L'invention concerne un nouveau dérivé d'arylthiadiazole représenté par la formule générale (I) et utile dans un traitement préventif ou thérapeutique contre des infections virales humaines, ou ses sels, ainsi qu'un agent aintiviral le contenant. Dans ladite formule R?1¿, R?2¿ et R?3¿ représentent chacun hydrogène, halogéno, alkyle C¿1?-C¿6?, trifluorométhyle, alcoxy C¿1?-C¿4?, hydroxy, nitro etc.; A représente (a), (b), (c), etc.; Y?1¿ représente oxygène ou soufre; W représente oxygène ou soufre; R?4¿ et R?5¿ représentent chacun hydrogène; alcoxy C¿1?-C¿4?, etc.; R?9¿ et R?10¿ représentent chacun hydrogène ou alkyle C¿1?-C¿6?; R?14¿ représente hydrogène, alkyle C¿1?-C¿6?, etc.; et n représente 0 ou 1.
Baba Masanori
Fujiwara Masatoshi
Hanasaki Yasuaki
Ide Teruhiko
Ijichi Katsushi
Ogilvy Renault
Rational Drug Design Laboratories
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