Arylthiazolidinedione and aryloxazolidinedione derivatives

Details Arylthiazolidinedione and aryloxazolidinedione derivatives Arylthiazolidinedione and aryloxazolidinedione derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/10 (2006.01) A61K 31/422 (2006.01) A61K 31/424 (2006.01) A61K 31/427 (2006.01) A61K 31/5377 (2006.01) C07D 263/04 (2006.01) C07D 263/44 (2006.01) C07D 263/57 (2006.01) C07D 277/04 (2006.01) C07D 277/34 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2377246

Substituted 5-aryl-2,4-thiazolidinediones and oxazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR .alpha. and/or .gamma. mediated diseases, disorders and conditions.

L'invention concerne des 5-aryle-2,4-thiazolidinediones et oxazolidinediones substituées, qui sont des agonistes puissants vis-à-vis du PPAR, et qui sont donc utiles pour le traitement, le contrôle et la prévention des affections suivantes : diabète, hyperglycémie, hyperlipidémie (y compris l'hypercholestérolémie et l'hypertriglycéridémie), athérosclérose, obésité, resténose vasculaire et autres maladies, troubles ou états dont la médiation est assurée par le PPAR .alpha. et/ou .gamma..

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