Arylthiazolidinedione derivatives

Details Arylthiazolidinedione derivatives Arylthiazolidinedione derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/34 (2006.01) A61K 31/425 (2006.01) C07D 263/44 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2315397

Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia), atherosclerosis, obesity, vascular restenosis, and other PPAR .alpha., .delta. and/or .gamma. mediated diseases, disorders and conditions.

L'invention porte sur des aryl-2,4-thiazolidinediones substituées à la position 5 qui sont de puissants agonistes de PPAR (Récepteur activé par le proliférateur de peroxisome), et par conséquent, utiles dans le traitement, la suppression ou la prévention des diabètes, de l'hyperglycémie (y compris l'hypercholestérolémie et l'hypertriglycéridémie), l'athérosclérose, l'obésité, la resténose vasculaire et autres maladies, troubles et états induits par PPAR alpha , delta et/ou gamma .

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