Arylthiazolylimidazoles as 5ht3 antagonists

C - Chemistry – Metallurgy – 07 – D

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167/225, 167/234

C07D 417/06 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2016181

Arylthiazolylimidazoles as 5HT3 antagonists useful in the treatment of nausea, anxiety, pain, schizophrenia and gastrointestinal disorders. Ar-HET-CH2-X wherein Ar is pyridyl, 3-indolyl; 8-quinolyl, phenyl or mono- or disubstituted phenyl wherein the substituent is each methyl, methoxy, fluoro, chloro or bromo; HET is thiazolyl; and X is imidazole or mono- or dimethylimidazole.

Les arylthiazolylimidazoles sont utiles, comme antagonistes de 5HT3, pour le traitement de la nausée, de l'anxiété, de la douleur, de la schizophrénie et des troubles gastro-intestinaux. Dans Ar-HET-CH2-X, Ar est un groupe pyridyle, 3-indolyle, 8-quinolyle, phényle ou phényle avec mono- ou disubstitution, le substituant étant un groupe méthyle, méthoxy, fluoro, chloro ou bromo; HET est un thiazolyle; enfin, X est un imidazole ou un mono- ou diméthylimidazole.

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