Ascorbate-stabilized radiopharmaceutical method and composition

Details Ascorbate-stabilized radiopharmaceutical method and composition Ascorbate-stabilized radiopharmaceutical method and composition

A - Human Necessities

61

K

A61K 51/00 (2006.01) A61K 51/08 (2006.01) A61M 36/14 (2006.01)

Patent

CA 2279349

The subject invention relates to the use of ascorbic acid and derivatives thereof in stabilizing radiolabeled proteins and peptides against oxidation loss of radiolabel and autoradiolysis. Ascorbic acid is added after radiolabeling, including any required incubation period, but prior to patient administration.

Utilisation d'acide ascorbique et de ses dérivés pour stabiliser des protéines et des peptides radiomarqués en évitant la perte du radio marquage par oxydation et l'autoradiolyse. L'acide ascorbique est ajouté après le radiomarquage, avec éventuellement la période d'incubation requise, mais avant l'administration au patient.

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