Asialoglycoprotein-conjugated medicinal agent

Details Asialoglycoprotein-conjugated medicinal agent Asialoglycoprotein-conjugated medicinal agent

C - Chemistry, Metallurgy

07

K

C07K 14/555 (2006.01) A61K 38/17 (2006.01) A61K 38/21 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2089881

2089881 9222310 PCTABS00018 The present invention relates to a conjugated medicinal agent prepared by combining asialoglycoprotein with a medicine which acts specifically on the liver. The conjugated medicinal agent of the present invention has the following formula (I): P-(S)x-Gal-GA-R, wherein in the P-(S)x-moiety, P is a peptide residue of a human serum glycoprotein and S is a sugar residue of a human serum glycoprotein; Gal is galactose residue; GA is glutaraldehyde residue; x is an integer equal to or greater than 1; and R is a medicinal component selected from the group consisting of interferon, acyclovir sodium, ribavirin, vidarabine, zidovudine, suramin, anti-sense oligonucleotide, ribozyme, leucovorin calcium, sodium-meglumine diatrizoate, gadolinium-DTPA, glutathione (GSH), prostaglandins, 99mTc and 131I. The present invention also includes a process for preparing the conjugated medicinal agent of formula (I), a pharmaceutical composition containing the conjugated medicine and the use of the conjugated medicine.

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