Asip-related proteins

Details Asip-related proteins Asip-related proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2434042

The invention provides cDNAs which encode ASIP-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly bladder transitional cell carcinoma. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

L'invention concerne des ADNc qui codent des protéines apparentées à la protéine ASIP. Elle concerne aussi l'utilisation des ADNc, de fragments, de compléments et de variantes de ces derniers et des protéines codées, des parties de ces dernières et des anticorps pour le diagnostic et le traitement du cancer, en particulier, du carcinome transitionnel de la vessie. L'invention traite aussi de vecteurs d'expression et de cellules hôtes pour la production de la protéine et d'un système de modèle transgénique.

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