Aspartic acid derivatives, their preparation and use

Details Aspartic acid derivatives, their preparation and use Aspartic acid derivatives, their preparation and use

C - Chemistry, Metallurgy

07

K

C07K 5/062 (2006.01) A61K 31/195 (2006.01) A61K 31/445 (2006.01) A61K 38/05 (2006.01) C07C 279/08 (2006.01) C07C 279/14 (2006.01) C07D 207/09 (2006.01) C07D 211/34 (2006.01) C07D 211/40 (2006.01) C07D 295/215 (2006.01) C07K 5/06 (2006.01) C07K 5/072 (2006.01) C07K 5/083 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2093770

Aspartic acid derivatives of the formula (see formula I) in which X denotes, for example, (see formula II) and R denotes, for example, cyclohexylamino, have useful pharmacological properties. In particular, they have the ability to inhibit the binding of fibrinogen, fibronectin and von Willebrand factor to integrin receptors. They also inhibit platelet aggregation, metastasis of carcinoma cells and osteoclast formation on bone surfaces and are useful in prophylaxis and therapy of, for example, arterial vascular diseases and in the treatment of tumors.

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