C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/26 (2006.01) A61K 31/445 (2006.01) A61K 31/453 (2006.01) A61P 9/00 (2006.01) C07D 211/22 (2006.01) C07D 401/12 (2006.01) C07D 407/12 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2628952
The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.
La présente invention concerne des inhibiteurs de protéase aspartique. Certains inhibiteurs de protéase aspartique de l'invention peuvent être représentés par la formule structurale suivante ou un sel pharmaceutiquement acceptable de celle-ci. La présente invention concerne en outre des compositions pharmaceutiques comprenant les inhibiteurs de protéase aspartique décrits. La présente invention concerne en outre des procédés d'antagonisation d'une ou plusieurs protéases aspartiques chez un sujet nécessitant celle-ci, et des procédés pour traiter un trouble véhiculé par la protéase aspartique chez un sujet utilisant les inhibiteurs de protéase aspartique décrits.
Baldwin John J.
Cacatian Salvacion
Claremon David A.
Dillard Lawrence W.
Flaherty Patrick T.
Gowling Lafleur Henderson Llp
Vitae Pharmaceuticals Inc.
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