Aspartic protease inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 233/90 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) A61K 38/05 (2006.01) C07D 231/14 (2006.01) C07D 233/28 (2006.01) C07D 249/04 (2006.01) C07D 263/34 (2006.01) C07D 277/56 (2006.01) C07D 487/08 (2006.01) C07F 7/10 (2006.01) C07F 9/547 (2006.01) C07F 9/6503 (2006.01) C07K 5/065 (2006.01)

Patent

CA 2280633

The present invention is directed to aspartic protease inhibitors, in particular to HIV protease, renin, pepsin and cathepsin D inhibitors. Inhibitors of the present invention have a 3 to 12-membered heterocyclic core containing at least two heteroatoms which interact with the carboxyl groups of the aspartic acid residues in the active site of the protease to inhibit the action thereof.

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