Aspartyl-.beta. substituted phenylalanines

C - Chemistry – Metallurgy – 07 – C

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C07C 229/34 (2006.01) C07C 271/12 (2006.01) C07D 339/00 (2006.01)

Patent

CA 1280429

ASPARTYL-.beta. SUBSTITUTED PHENYLALANINES Abstract of the Disclosure Synthesis of phenylserine ester a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase: and b) via methyl benzoylacetate. Synthesis of hydroxy-aspartame or derivative by enzymatic coupling of phenylserine or derivative with aspartic acid or derivative. Hydrogenation of the coupled product to give as final product aspartame or analog with related processes and products.

520856

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