C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) C07K 14/81 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2498055
The present invention is broadly directed to novel nematode allergens (polypeptides) and associated amino acid and nucleotide sequences including functional fragments and variants thereof to identify animals that are capable of becoming naturally resistant to nematodes. In particular, the present invention concerns the use of these molecules to, assist in selective breeding of animals capable of becoming naturally resistant to nematode infections. More, particularly, the invention is directed towards the use of nucleic acid molecules and polypeptides, which are the same or functional variants of, aspartyl protease inhibitors: (Tco-Aspin), of Trichostrongylus colubriformis; and/or (Oc-Aspin), of Ostertagia circumcincta; and/or (Hc-Aspin) Haemonchus contortus in identifying animals that are innately more disposed to nematodes.
La présente invention se rapporte de manière générale à de nouveaux allergènes de nématodes (polypeptides) et aux séquences nucléotidiques et d'acides aminés associées comprenant des fragments fonctionnels et leurs variants afin d'identifier les animaux aptes à devenir naturellement résistants aux nématodes. La présente invention se rapporte plus particulièrement à l'utilisation de ces molécules afin de nourrir de manière sélective les animaux aptes à devenir naturellement résistants aux infections de nématodes. L'invention se rapporte plus précisément à l'utilisation de molécules d'acides nucléiques et de polypeptides identiques ou constituant des variants fonctionnels d'inhibiteurs de la protéase aspartyle: (Tco-Aspin), de Trichostrongylus colubriformis; et/ou (Oc-Aspin), de Ostertagia circumcincta; et/ou (Hc-Aspin) Haemonchus contortus dans l'identification des animaux qui sont naturellement plus enclins à développer une résistance contre des infections causées par des nématodes.
Maass David Richard
Mcneill Margaret Mary
Shaw Richard John
Shoemaker Charles Bix
Gowling Lafleur Henderson Llp
Ovita Limited
LandOfFree
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