Aspartyl protease inhibitors

Details Aspartyl protease inhibitors Aspartyl protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2609582

Disclosed are compounds of the formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein j, k, U, W, R, R1, R2, R3, R4, R6, R7 and R7a are as described above in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula (I) in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

Cette invention concerne des composés représentés par la formule (I) ou un stéréo-isomère, un tautomère ou un sel ou un solvate pharmaceutiquement acceptable de ceux-ci; dans cette formule, j, k, U, W, R, R1, R2, R3, R4, R6, R7 et R7a sont tels que définis dans la spécification. Cette invention concerne également un procédé permettant d'inhiber l'aspartyl protéase, et plus particulièrement, des méthodes permettant de traiter des maladies cardio-vasculaires, des maladies cognitives et neurodégénératives. En outre cette invention concerne des méthodes permettant de traiter des maladies cognitives ou neurodégénératives au moyen de composés représentés par la formule (I) conjointement avec un inhibiteur de cholinestérase ou un agoniste muscarinique m1 ou un antagoniste m2.

Affiliated with

Also associated with

Rating

Aspartyl protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aspartyl protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aspartyl protease inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1623516