C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/70 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 493/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2672295
Disclosed are compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof or wherein R1, R2, R3, R4, R6, R7, R14, W, V, X, Y, A and b are as described above in the specification. Also disclosed is a method of inhibiting aspartyl protease, methods of treating cardiovascular diseases, cognitive diseases, neurodegenerative diseases, and other biological processes and indications. Combination treatments and compositions are also disclosed.
L'invention concerne des composés représentés par la formule (I) ou un stéréoisomère, un tautomère, ou un sel ou un solvate pharmaceutiquement acceptable de ceux-ci, dans laquelle R1, R2, R3, R4, R6, R7, R14, W, V, X, Y, A et b sont tels que décrits ci-dessus dans la description. L'invention concerne également un procédé destiné à inhiber la protéase aspartyle, des procédés destinés à traiter des maladies cardio-vasculaires, des maladies cognitives, des maladies neurodégénératives et d'autres processus biologiques et indications. L'invention concerne également des polythérapies et des compositions.
Li Guoqing
Mandal Mihirbaran
Stamford Andrew
Zhu Zhaoning
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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