Aspb1 insulin analogs

Details Aspb1 insulin analogs Aspb1 insulin analogs

C - Chemistry, Metallurgy

07

K

C07K 14/62 (2006.01) A61K 38/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2196569

Analogs of humain insulin containing an aspartic acid at position 1 of the B chain (AspB1), and optionally, having a gln modification at position 13 (GlnB13), display modified physico-chemical and pharmacokinetic properties which enable them to be long acting. These analogs are useful in the treatment of hyperglycemia because they are soluble and display an increased tendency to self-associate.

Cette invention se rapporte à des analogues de l'insuline humaine, qui contiennent un acide aspartique à la position 1 de la chaine B (Asp?B1¿), et qui présentent éventuellement une modification gln à la position 13 (Gln?B13¿). Ces composés ont des propriétés physicochimiques et pharmacocynétiques modifiées, qui leur permettent d'être actifs longtemps. Ces analogues sont utiles dans le traitement de l'hyperglycémie, parce qu'ils sont solubles et qu'ils ont une tendance accrue à s'auto-associer.

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