C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/26 (2006.01) C07K 14/58 (2006.01) G01N 33/543 (2006.01) G01N 33/577 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2248140
The present invention provides reagents and assays for the quantification of hBNP in biological fluid samples such as plasma or serum. Antibodies are provided which are monospecific to epitopes comprising the amino acid sequences 5-13, 1-10 and 15-25 of hBNP. These antibodies, and peptide fragments containing these sequences, can be employed in the assays of the invention, which may be carried out in a sandwich format or a competition format.
La présente invention concerne des réactifs ainsi que des analyses permettant de quantifier le hBNP dans des échantillons de fluides biologiques, tel que du plasma ou du sérum. Cette invention concerne également des anticorps qui sont monospécifiques aux épitopes comprenant les séquences d'acide aminé 5-13, 1-10 et 15-25 du hBNP. Ces anticorps, ainsi que des fragments de peptides contenant ces séquences, peuvent être utilisés dans les analyses faisant l'objet de l'invention, lesquelles peuvent être réalisées sous un format de type sandwich ou de type compétition.
Lim Garrett A.
Mischak Ronald P.
Scardina Jan Marian
Borden Ladner Gervais Llp
Scios Inc.
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