Assay for adrenal autoantigen

Details Assay for adrenal autoantigen Assay for adrenal autoantigen

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A61K 35/14 (2006.01) A61K 35/18 (2006.01) A61K 38/44 (2006.01) C12N 1/19 (2006.01) C12N 5/08 (2006.01) C12N 9/02 (2006.01) G01N 33/564 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2131539

2131539 9318406 PCTABS00025 Adrenal autoantigen is isolated and characterised as a protein obtainable from the microsome fraction of the adrenal gland, having a molecular weight of about 50,000 to 60,000 and antigenic towards adrenal autoantibody. The protein innative, recombinant or modified form as well as fragments thereof comprising an epitope for adrenal autoantibody are used in a method and kit for detecting adrenal autoantibodies. The protein is also useful as a medicament for treating Addisson's disease. Absorption studies show that the autoantigen is steroid 21-hydroxylase.

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