C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 2/00 (2006.01) A61K 38/46 (2006.01) C07K 14/085 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2431813
There is provided an assay for selecting an anti-viral agent effective against picornavirus infection. The assay selects ann agent which disrupts the association between picornavirus protein 2C and the host cell protein D-AKAP2, which association has been found to be essential for successful viral replication. Also disclosed are anti-viral agents having such properties and a method of combating picornavirus replication.
L'invention concerne un dosage de sélection d'un agent antiviral efficace contre une infection picornavirale. Le dosage sélectionne un agent interrompant l'association entre la protéine 2C de picornavirus et la protéine D-AKAP2 de cellule hôte, association ayant été découverte comme étant essentielle à une réplication virale réussie. L'invention concerne également des agents antiviraux présentant ces propriétés et une méthode de combat de la réplication de picornavirus.
Knox Caroline
Ryan Michael
Wileman Tom
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The University Court Of The University Of St Andrews
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