Assay for blood clotting factors viii and ix

Details Assay for blood clotting factors viii and ix Assay for blood clotting factors viii and ix

C - Chemistry, Metallurgy

12

N

C12N 9/48 (2006.01) C12Q 1/56 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2236155

An assay has been developed to detect the presence of blood clotting factors, including factors VIII and IX, utilizing mutated tissue factor. Mutated forms of wild type tissue factor as well as various forms of truncated tissue factor can be used. Preferably, substitutions of glutamine, alanine, glutamic acid, or combinations thereof are made at amino acid positions 165, 166 or 165 and 166. Various tissue factor mutants exhibit different extents of activity in supporting FVIII and FIX activation: Q165Q166 > A165A166 > E165E166.

Un essai de dosage a été mis au point pour détecter la présence de facteurs de coagulation sanguine, y compris les facteurs VIII et IX, utilisant des facteurs tissulaires mutés. Des formes mutées de facteurs tissulaires de type sauvage ainsi que diverses formes de facteurs tissulaires tronqués peuvent être utilisées. De préférence, des substitutions de glutamine, d'analine, d'acide glutamique ou de combinaisons de ceux-ci sont effectuées aux positions 165, 166 ou 165 et 166 des acides aminés. Divers mutants de facteurs tissulaires possèdent différentes ampleurs d'activités dans leur soutien à l'activation de FVIII et FIX: Q?165¿Q?166¿ > A?165¿A?166¿ > E?165¿E?166¿.

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