C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/26 (2006.01) G01N 33/567 (2006.01) G01N 33/86 (2006.01)
Patent
CA 2582627
A Rapid And Sensitive Radiometric Assay For Assessing The Activity Of Cytochrome P-450 (CYP) 2C9 And The Potential Of An Analyte To Inhibit CYP2C9 Activity Or Induce CYP2C9 Expression is described. All the steps of the assay, including incubations, product separation, and radioactivity counting are preferably performed in a multiwell format, which can be automated.
L'invention porte sur un essai radiométrique rapide et sensible d'évaluation de l'activité de cytochrome P-450 (CYP) 2C9 et de la puissance d'un analyte pour inhiber l'activité de CYP2C9 ou pour induire l'expression de CYP2C9. Toutes les étapes de l'essai, y compris les incubations, la séparation de produit et le comptage de radioactivité sont réalisées de préférence dans un format à puits multiples, qui peut être automatisé.
Chaudhary Ashok
Di Marco Annalise
Laufer Ralph
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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