Assay for cytochrome p450 isoforms 3a4 and 3a5

Details Assay for cytochrome p450 isoforms 3a4 and 3a5 Assay for cytochrome p450 isoforms 3a4 and 3a5

C - Chemistry, Metallurgy

12

Q

C12Q 1/26 (2006.01)

Patent

CA 2582564

A rapid and sensitive radiometric assay for assessing the activity of cytochrome P-450 (CYP) 3A4/5 and the potential of an analyte to inhibit CYP3A4/5 activity or induce CYP3A4/5 expression is described. All the steps of the assay, including incubations, product separation, and radioactivity counting are preferably performed in a multiwell format, which can be automated.

L'invention concerne un dosage radiométrique rapide et sensible pour évaluer l'activité du cytochrome P-450 (CYP) 3A4/5 et le pouvoir d'un analyte d'inhiber l'activité du CYP3A4/5 ou d'induire l'expression du CYP3A4/5. Il est préférable d'effectuer toutes les étapes du dosage, y compris les incubations, la séparation de produits, et le comptage de la radioactivité, en format à puits multiples, ce que l'on peut automatiser.

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