Assay for detecting cathepsin k activity in bone, cartilage...

Details Assay for detecting cathepsin k activity in bone, cartilage... Assay for detecting cathepsin k activity in bone, cartilage...

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) C12Q 1/37 (2006.01) G01N 33/574 (2006.01) C07K 7/06 (2006.01) C07K 14/78 (2006.01) C12N 9/64 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2669470

There is provided a method for detecting cathepsin K activity in bone, cartilage and/or connective tissue, the method comprising providing a biological sample, contacting the sample with an antibody having binding specificity for a neoepitope comprising EAGKPG (SEQ ID NO: 9), and detecting an immunocomplex formed between the antibody and the neoepitope, wherein presence of the immunocomplex is indicative of cathepsin K activity in bone, cartilage and/or connective tissue. There is also provided a kit for detecting cathepsin K activity in bone, cartilage and/or connective tissue.

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