Assay for detecting damage to the central nervous system

Details Assay for detecting damage to the central nervous system Assay for detecting damage to the central nervous system

G - Physics

01

N

G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2381275

A method is disclosed for the rapid diagnosis of disorders characterized by an ischemic event, such as stroke, transient ischemic attack, head trauma, myocardial infarction, or other insults resulting in interrupted cranial blood flow. The method involves detection of the presence of the gamma isoform of protein kinase C (PKCg) in peripheral blood, which signals damage to central nervous system tissue and at least transient breakdown of the blood brain barrier. The assay may be performed, e.g., by emergency medical personnel, in a time frame that allows treatment of the patient before permanent damage to the central nervous system occurs.

L'invention concerne un procédé de diagnostic rapide de troubles caractérisés par un événement ischémique, tel qu'un ictus, un accident ischémique transitoire, un traumatisme crânien, un infarctus du myocarde, ou d'autres accidents provoquant une interruption du débit sanguin cérébral. Ce procédé consiste à détecter la présence de l'isoforme gamma de la protéine kinase C (PKCg) dans le sang périphérique, laquelle signale une lésion du tissu du système nerveux central ainsi qu'au moins une rupture transitoire de la barrière hémato-encéphalique. Un personnel médical d'urgence peut exécuter ce dosage, dans un laps de temps permettant de traiter le patient avant qu'une lésion permanente du système nerveux central ne se produise.

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