G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/577 (2006.01) G01N 1/34 (2006.01) G01N 33/86 (2006.01)
Patent
CA 2112228
2112228 9300364 PCTABS00019 This invention provides a method of detecting the presence of an A.alpha. fragment in a fibrinogen- or fibrinogen derivative-containing sample from a human subject which comprises: contacting the sample with an agent capable of forming a complex with intact fibrinogen, or with a fibrinogen derivative which contains an A.alpha. chain under conditions permitting formation of a complex; removing a complex so formed from the sample; contacting the resulting sample with a monoclonal antibody capable of forming a complex with an epitope containing amino acid residues present exclusively between amino acid residue 477 and the carboxy terminus of the A.alpha. fragment, under conditions permitting formation of a monoclonal antibody A.alpha. fragment complex; and detecting any such complex formed in the sample, thereby detecting the presence of A.alpha. fragment in the sample.
Canfield Robert E.
Sobel Joan H.
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University
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