Assay for detecting infection by human t-cell leukemia virus

Details Assay for detecting infection by human t-cell leukemia virus Assay for detecting infection by human t-cell leukemia virus

C - Chemistry, Metallurgy

12

Q

167/37, 530/15.1

C12Q 1/70 (2006.01) G01N 33/53 (2006.01) C07K 3/00 (1985.01)

Patent

CA 1247082

ASSAY FOR DETECTING INFECTION BY HUMAN T-CELL LYMPHOTROPHIC VIRUS Abstract of the Disclosure A first glycoprotein having a molecular weight of approximately 120,000 daltons in the H9/HTLV-III cell line is obtained from cells infected with human T-cell leukemia virus, type III. A second glycoprotein having a molecular weight of approximately 160,000 da tons is also obtained from such cells, of which approximately 90,000 daltons contains substantially all of the antigenic determinants of the first and of the second glycoprotein. The presence, in a biological specimen such as blood or saliva, of either of specific glycoproteins or of the unglycosylated moiety is indicative of infection by human T-cell lymphotrophic virus. An assay for the glycoprotein or its unglycosylated moiety is a useful diagnostic procedure for determining such infection.

495112

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