C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/56 (2006.01) C12Q 1/37 (2006.01) G01N 33/86 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2171721
An assay useful for detecting the propensity of patients for thrombotic disease, especially patients having the lupus anticoagulant or antiphospholipid antibodies, is described. The assay is conducted on patient and control plasma in the presence and absence of exogenous Protein C with a membrane source comprising phosphatidylethanolamine and phosphatidylserine. Patients at risk exhibit test results indicating activated Protein C function is inhibited.
Dosage permettant de détecter chez des patients un risque accrû d'affections thrombotiques, en particulier des patients présentant les anticorps antiphospholipides ou anticoagulants lupiques. Le dosage est effectué sur le plasma d'un patient et un plasma témoin en présence et en l'absence d'une protéine C exogène, avec une source membranaire comprenant la phosphatidyléthanolamine et la phosphatidylsérine. Les patients à risque soumis au dosage présentent des résultats indiquant une inhibition de la fonction de la protéine C activée.
Esmon Charles T.
Smirnov Mikhail D.
Kirby Eades Gale Baker
Oklahoma Medical Research Foundation
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