Assay for determining sensitivity to activated protein c

Details Assay for determining sensitivity to activated protein c Assay for determining sensitivity to activated protein c

C - Chemistry, Metallurgy

12

Q

C12Q 1/56 (2006.01)

Patent

CA 2137041

An improved assay for determining sensitivity to activated protein C in test samples has been developed to ensure rapid and accurate evaluations. This assay is based on measuring the conversion, by activated factor VIII within a test sample, of added factor X to an activated form. The activated protein C sensitivity of the test sample is determined by the relative inhibition of factor X conversion as compared to a control. A test sample that has decreased sensitivity to activated protein C will show relatively low inhibition, and vice versa.

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