G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/72 (2006.01) G01N 33/566 (2006.01) G01N 33/66 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2096250
There is provided a method of assessing a glycated blood protein in a sample, said method comprising the steps of a) op- tionally hemolysing said sample to liberate cell bound glycated protein; b) separating said glycated blood protein and the corre- sponding non-glycated blood protein from said sample; c) contacting said sample before or during separation of said glycated and non-glycated proteins therefrom or contacting said separated proteins with a first signal forming agent capable of binding to said glycated protein but not to the corresponding non-glycated protein; d) optionally, contacting said sample before or during separation of said glycated and non-glycated proteins therefrom or contacting said separated proteins with a second signal form- ing agent capable of binding to said glycated protein and to said corresponding non-glycated protein; and e) assessing the signal forming agents which have bound to said separated proteins and/or which have not bound to said glycated protein or said corre- sponding non-glycated protein; with the proviso that where said glycated protein comprises glycated hemoglobin said first signal forming agent is a chromophore labelled boronic acid or salt thereof having an absorption maximum at above 600 nm. In this method the glycated protein which is labelled by the first signal forming agent may be any one, or indeed any set, of the blood proteins. By appropriate selection of the proteins under assay an indication may be obtained of the history of the patient's blood glucose control over the short, medium and long (up to 3 months) term.
Frantzen Frank
Sundrehagen Erling
Axis Biochemicals Asa
Axis Research As
Kirby Eades Gale Baker
LandOfFree
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