G - Physics – 01 – N
Patent
G - Physics
01
N
150/15, 167/43
G01N 33/543 (2006.01) G01N 21/63 (2006.01) G01N 33/58 (2006.01)
Patent
CA 1255213
ABSTRACT A sensitive and specific assay method for luminescent detection of support matrix-bound reporter groups smaller than about 10,000 daltons in size is disclosed which comprises contacting such reporter groups with a detector complex which comprises a first component having a strong and specific affinity for such reporter groups, and a second component capable of being readily coupled to a bioluminescent or chemi- luminescent light emitting system, thereby to produce high affinity attachment of said detector complex to the immobilized reporter group. The amount of bound detector complex is determined with a luminescence coupled reaction. The light emitted is quantitated by means including a luminometer, light sensitive film, or light sensitive charge coupled device; and the amount of such light provides a measure of the reporter groups bound to the support matrix. In one application, the assay method provides means for monitoring the inter- actions by which the reporter groups are immobilized. Also disclosed are reagent means useful in practicing the method.
472029
Molecular Biosystems Inc.
Osler Hoskin & Harcourt Llp
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