Assay for in vitro quantititive measurement of...

Details Assay for in vitro quantititive measurement of... Assay for in vitro quantititive measurement of...

G - Physics

01

N

167/37, 195/1.11

G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1340799

A method of analyzing a body fluid sample for the presence of an analyte indicative of type I collagen degradation in vivo, is provided. The method comprises the steps of contacting a body fluid sample with an immunological binding partner, which is capable of binding to the analyte, and detecting any binding of the immunological binding partner in the body fluid sample. Subsequent correlation of the detected binding to type I collagen degradation in vivo, is then conducted. The immunological binding partner is capable of binding to a peptide containing a 3-hydroxypyridinium cross-link and comprising two amino acid sequences derived from the carboxy-terminal telopeptide domain of the .alpha.1(I) chain of type I collagen.

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