Assay for inhibitors of dp-1 and other dp proteins

Details Assay for inhibitors of dp-1 and other dp proteins Assay for inhibitors of dp-1 and other dp proteins

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) G01N 33/60 (2006.01)

Patent

CA 2193091

The protein DP-1, part of the DP-1/E2F-1 transcription factor complex, as well as DP-2 and DP-3 has its phosphorylation level regulated during cell cycle progression. This finding allows assays to be based on changes in phosphorylation of DP proteins, in particular for agents which may affect the phosphorylation state of DP. DP-1 has been found to have a greater affinity to DNA when in a hypophosphorylated state. Also disclosed are antibodies that recognise phosphorylation sites on DP-1.

On a découvert que le niveau de phosphorylation de la protéine DP-1, d'une partie du complexe du facteur de transcription DP-1/E2F1 ainsi que celui des protéines DP-2 et DP-3, était régulé au cours de la progression du cycle cellulaire. Cette découverte permet de fonder les dosages sur des modifications de la phosphorylation des protéines DP, notamment pour des agents pouvant affecter l'état de phosphorylation de DP. On a remarqué que DP-1 présente une affinité plus forte pour l'ADN lorsqu'elle se trouve dans un état hypophosphorylé. On décrit également des anticorps qui reconnaissent les sites de phosphorylation sur DP-1.

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