A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/74 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2468082
The invention relates to an assay to select a candidate drug for the treatment of inflammatory disease due to cytokine production. The assay comprises: a) exposing said candidate drug to intestinal cells; and b) analysing the effect of the said candidate drug selected from the group consisting of the variation of nuclear export or import of transcription factors from the NF-.kappa.B family the disruption of transcriptional activity of transcription factors from the NF-.kappa.B family, the differential histone acetylation of p65 (RelA); the variation of the amount of PPAR.gamma./RelA complexes in the cytosol of the cells; and the variation in the levels of one or more cytokines. The invention further relates to methods for the treatment of inflammatory cytokine production associated diseases and to the use of a therapeutically effective dose of Bacteroides thetaiotaomicron or a component thereof.
L'invention concerne une technique destinée à sélectionner un médicament candidat pour le traitement d'une maladie inflammatoire causée par une production de cytokine. Cette technique consiste à: (a) exposer ledit médicament candidat à des cellules intestinales; et (b) analyser l'effet dudit médicament candidat sélectionné dans le groupe comprenant la variation d'exportation ou d'importation nucléaire de facteurs de transcription de la famille NF-kB, l'interruption d'activité transcriptionnelle de facteurs de transcription de la famille NF-kB, l'acétylation d'histone différentielle de p65 (RelA), la variation de la quantité de complexes de PPAR.gamma./RelA dans le cytosol des cellules, et la variation dans les niveaux d'une ou de plusieurs cytokines. L'invention concerne en outre des méthodes de traitement de maladies inflammatoires associées à la production de cytokine, et l'utilisation d'une dose thérapeutiquement efficace de Bacteroides thetaiotaomicronou d'un composant de celui-ci.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Rowett Research Institute
The University Court Of The University Of Aberdeen
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