Assay for screening candidate drugs for the treatment of...

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 35/74 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2468082

The invention relates to an assay to select a candidate drug for the treatment of inflammatory disease due to cytokine production. The assay comprises: a) exposing said candidate drug to intestinal cells; and b) analysing the effect of the said candidate drug selected from the group consisting of the variation of nuclear export or import of transcription factors from the NF-.kappa.B family the disruption of transcriptional activity of transcription factors from the NF-.kappa.B family, the differential histone acetylation of p65 (RelA); the variation of the amount of PPAR.gamma./RelA complexes in the cytosol of the cells; and the variation in the levels of one or more cytokines. The invention further relates to methods for the treatment of inflammatory cytokine production associated diseases and to the use of a therapeutically effective dose of Bacteroides thetaiotaomicron or a component thereof.

L'invention concerne une technique destinée à sélectionner un médicament candidat pour le traitement d'une maladie inflammatoire causée par une production de cytokine. Cette technique consiste à: (a) exposer ledit médicament candidat à des cellules intestinales; et (b) analyser l'effet dudit médicament candidat sélectionné dans le groupe comprenant la variation d'exportation ou d'importation nucléaire de facteurs de transcription de la famille NF-kB, l'interruption d'activité transcriptionnelle de facteurs de transcription de la famille NF-kB, l'acétylation d'histone différentielle de p65 (RelA), la variation de la quantité de complexes de PPAR.gamma./RelA dans le cytosol des cellules, et la variation dans les niveaux d'une ou de plusieurs cytokines. L'invention concerne en outre des méthodes de traitement de maladies inflammatoires associées à la production de cytokine, et l'utilisation d'une dose thérapeutiquement efficace de Bacteroides thetaiotaomicronou d'un composant de celui-ci.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Assay for screening candidate drugs for the treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Assay for screening candidate drugs for the treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay for screening candidate drugs for the treatment of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1594208

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.